What happens when you throw bones to a group of American alligators? This isn’t a question for late night horror movies, but for science.

Standing behind a safety barrier at Florida’s St. Augustine Alligator Farm, University of Tennessee paleontologist Stephanie Drumheller tossed skeletonized cow legs to a crush of curious alligators. Over and over again, the armored archosaurs rushed in to snap at the morsels, and with every bite they left the predatory hallmarks in the form of punctures and scrapes. These traces were what Drumheller was after. Through understanding the damage modern alligators leave on bones, Drumheller and other paleontologists can follow the depredations of alligators and their croc cousins through time.

This process is rarely found in mammalian cells and this has been suggested as the basis for their poor regenerative abilities. But clearly, unraveling the mechanisms underlying this reprogramming is central to understanding why certain vertebrates can regenerate their limbs while others can’t, and how to repeat this process in humans.

If we were able to crack this puzzle, it could lead to strategies to enhance the reprogramming of cells from patients, and to better understand their disease and design appropriate cures.

We recently found a critical component of the reprogramming mechanism. In our study, published in Stem Cell Reports, we demonstrated that the sustained activation of a molecular pathway (a group of molecules in a cell that work together to control a particular function or functions) – called the ERK pathway – plays a key role during the natural reprogramming of salamander muscle cells. Only when the ERK pathway is constantly switched “on” are the cells able to re-enter the cell cycle, which is key to their regenerative potential.

The best way to prevent a disease from turning into an epidemic is to closely monitor its development and put systems in place before it starts spreading rapidly through populations. This requires surveillance and monitoring of the disease and disease populations. This is fine for populations of livestock, or humans, but tends to be a neglected area when it comes to animals in the wild. There are plenty of examples of devastating diseases that have ranged through wild-animal populations relatively unchecked until the later stages as they were simply not caught early enough.

An example is the fungal skin infection of frogs (chytridiomycosis) which absolutely decimated amphibians, wiping out about 200 frog species world wide. Yet investigations into the disease didn’t start until 15 years after its initial appearance.

The scientists said in a new study, published in the journal Nature Communications on Wednesday, that during the Mesozoic era, about 252 to 66 million years ago, the seas were full of reptiles like the nothosaur. While scientists knew that these creatures were predators with long bodies and paddle-like limbs, exactly how they used their limbs to propel themselves through water was unknown. Now, recently discovered trackways on an ancient seabed in Yunnan province in southwestern China, have helped scientists find an answer.

Like several of the state's recognized symbols, the beginnings of the wood frog push came in an elementary school classroom. Sen. John DeFrancisco, R-Syracuse, first introduced the bill last year after 9-year-old Lili Winkelman, a Skaneateles fourth-grader, wrote to him with the idea.

"You probably don't know this, but the wood frog is already the unofficial amphibian of the state," DeFrancisco said on the Senate floor. "A young girl in that class, Lili Winkelman, thought, why is that? She loves frogs. Why should it be unofficial?"

Winkelman followed up the letter with a 4 -1/2-minute YouTube video in January, in which she spoke about the unique qualities of the amphibian as photos of the frog float above her right shoulder — not unlike a television news anchor. Each of her classmates at Skaneateles' State Street Intermediate School followed up with a letter, DeFrancisco said.